免疫耐受临本课件.ppt

* * * * * * * * * Clonal anergy: Auto-reactive T cells when exposed to antigenic peptides that do not possess co-stimulatory molecules (B7-1 or B7-2) become anergic to the antigen. * Clonal ignorance: T cells reactive to self antigen not represented in the thymus will mature and migrate to the periphery, but they may never encounter the appropriate antigen because it is sequestered in inaccessible tissues. Such cells may die out for lack of stimulus. Auto-reactive B cells that escape deletion may not find the antigen or the specific helper T-cells and hence not be activated and die out.