P53对宫颈癌行顺铂新辅助化疗患者疗效和敏感性评估.PDFVIP

中国现代医生 2019年2月第57卷第6期 窑论 著 窑 S100A、P53对宫颈癌行顺铂新辅助化疗患者疗效 及敏感性评估 武晓敏 杨慧芬 浙江省丽水市中心医院妇产科袁浙江丽水 323000 [摘要] 目的探讨S100A6尧P53对宫颈癌行顺铂新辅助化疗患者的疗效及化疗敏感性评估价值遥 方法选取2017年 1耀12月我院收治的行顺铂新辅助化疗的宫颈癌患者70例袁观察不同临床疗效患者的S100A6尧P53表达情况遥 结果70例患者中完全缓解渊CR冤8例袁部分缓解渊PR冤51例袁疾病稳定渊SD冤6例袁疾病进展渊PD冤5例袁化疗总有效率 为84.29%渊59/70冤曰化疗前S100A6尧P53 阳性表达率为85.71%尧61.43%袁化疗后S100A6尧P53 阳性表达率为45.71%尧 84.29%袁化疗后S100A6 阳性表达率较化疗前明显降低渊P0.05冤袁P53 阳性表达率较化疗前明显升高渊P0.05冤曰高 敏感组 S100A6尧P53 阳性表达率分别为27.12%尧91.53%袁低敏感组 S100A6尧P53 阳性表达率分别为90.91%尧 45.45%袁高敏感组S100A6 阳性表达率明显低于低敏感组渊P0.05冤袁P53 阳性表达率明显高于低敏感组渊P0.05冤遥 结论S100A6尧P53可作为宫颈癌患者行顺铂新辅助化疗效果和敏感性预测的标志物遥 [关键词] S100A6曰P53曰宫颈癌曰顺铂新辅助化疗曰敏感性 [中图分类号] R737.3 [文献标识码] A [文章编号] 1673-9701渊2019冤06-0011-04 Evaluationonthe efficacyandsensitivity of S100AandP53inthe patients withcervicalcancerundergoing cisplatinneoadjuvantchemotherapy WUXiaomin YANGHuifen Departmentof Gynecologyand Obstetrics,Lishui Central HospitalinZhejiang Province, Lishui 323000,China [Abstract]ObjectiveTo investigate the efficacy of S100A6 and P53 in the patientswith cervical cancer receiving cis鄄 platin neoadjuvant chemotherapy and the evaluation value of chemosensitivity. Methods 70 patients with cervical can鄄 cerwho were admitted to ourhospital andwere given neoadjuvant chemotherapywith cisplatinfrom January to Decem鄄 ber 2017were selected.The expression of S100A6 and P53 inthe patients with different clinical efficacy was observed. Results Among the 70 patients, 8patients had complete remission(CR), 51 patients had partial remission (PR), 6 pa鄄 tients had stable disease(SD), and 5 patients had disease progression(PD). The total effective rate of chemother鄄