结直肠癌Pgp、CerbB２蛋白表达的临床意义.docVIP

结直肠癌Pgp、c—erbB— 2蛋白表达的临床意义 孙静阳1吕中2 裴笑月1孙海姣1李晓慧1胡波1 1?大连大学附属新华医院病理科辽宁大连1 1 6 0 2 1 ; 2 .大连 医科大学附属第二医院中心实验室 辽宁 大连116021 【 】 目的C—erbB—2、Pgp蛋白表达与CRC临床病理特征的关系. 方法 免疫组化检测蛋白表达,SPSS软件分析数据.结果C-erbB- 2蛋白表达 与临床病理特征均无统计学相关性(P 0?0 5 ).Pgp蛋白表达在大体溃疡型(8 6?8 8 %)与隆起型(7 5 . 5 1 %)间统计学差异显著(PV 0?0 5 );在肿瘤侵 润深度(肠壁浆膜层或累及临近器官9 0. 4 8 %、肠壁全层8 8. 4 2 %、肌 层7 2 . 2 2 %、粘膜下层6 0 %)间统计学差异显著(P 0?0 5 )；在淋巴结有 无转移(9 3 . 9 8 %, 7 5 .91 %)间统计学差异特别显著(PV 0?0 1 ).C—erbB —2与Pgp蛋白表达间无统计学相关性(P 0?0 5 ).结论 多数CRC可能有原 发性多药耐药;Pgp蛋白可作反映CRC牛物学行为的标志物，恶性程度较高的CRC 可能易出现原发性多药耐药.【关键词】C-erbB- 2 Pgp结直肠癌 多药 耐药 TheClinicalSignificanceofC —erbB— 2 an dPgpProtei nExpressi onsin ColorectalCarci noma [Abstract] Objective:ExplorethefeasibilitythatC—erbB— 2 an dPgpprotei nexpressio nsareusedtoassessbiologicalbehaviorsandprog no sisofcolorec taicancer. MethG odsJmmunohistochemistrywasusedtodetecttheproteinexpressions. SPSSstatisticsof twarewasusedtoa nalyzetherelati on shipoftheprotei nexpressio nstoclinicalpathoG logicalfeaturesofthecancerandthecorrelationbetweentheproteinexpressions. Result s:Theexpressi ono fC—erbB— 2 proteinhadnosignificantrelationstocharacteristicsofthecancers(P 0 ? 0 5 ). ThepositiveratesofPgpproteinexpressioningrossshapeofulcerandprotrusionwere 8 6. 8 8 %a nd 7 5. 5 1 %an dtherewasstatisticalsig n 讦 ican cebetwee nthem (P 0?0 5 ). Thepositiveratesininvasionstoadjacentorgansorpenetrationserosa,toserosaorad ventitia,tomuscleandtosubmucosawere 90. 48 %, 88 . 42 %, 72 . 2 2 % and 6 0 %respectivelyandtherewerestatisticalsigrdficancesamongthem(P 0 . 0 5). Thepositiveratesintumorwitha ndwithoutlymph no demetastasiswere 9 3. 9 8 % and 7 5 . 9 1 %andtherewasstatisticalsign讦icancebetweenthem (P 0 ? 0 1 ). TherewerenostatisticalcorrelationsbetweenexpressionsofC—erbB— 2 andPgpproteinincolorectalcancer(P 0 ? 0 5 ). Conclusions:Themajorcolorectalcancersmighthaveaprimarymultidrugresistanee ? PgpproteincanbeseenasapotentialmarkerforjudgeG ment [mKaelyignWaonrtdsb】 ehaviorofcolorectalca ncera ndthecolorectalca ncerwithhigh