青藤碱的制剂跟新新药代动力学研究探究 进展.pdfVIP

! 84! 2010 44 10 SH. J. TCM Oct., 2010; Vo.l 44 No. 10 综 述 1, 2 1 2 1 2 1. ( 8300 54) 2. ( 2 012 03) , ; , ; ; ; R285. 5 A 100 713 34 ( 20 10) 100 08406 S tudy p rogress on s inom en ine preparation and its pharm acok inetics 1, 2 1 2 1 2 WANG Huayang I Yan WEIHai MO Ju X ING Shuning 1. College of Pharmacy, X injiangMedicalUniversity 2. ShanghaiU niversity ofT raditional ChineseM edicine A bs tract: This article review s the sinom enine preparation and its pharm aceutics, including sustainedrelease preparations, controlledrelease preparations and transder m al drug delivery system s, and so on. A lso, this article expounds the pharm acokinetics of sinom enine from the perspectives ofm ethodology, physiological disposi tion and dosage form s etc, as w ell as the existing problem s and the developm ental direction. K ey word s: Sinom enine; preparation; pharm acokinetics; review S inom en ium acutum ( Thunb. ) R e (HPMC), hd. EtW ils. , , [ 12] [ 4] , HPMC [ 5] [ 6] 1 , ( Polycarbophil Crosslinked w ith Chitosan, PCC) HPMC, , , , ; , , [ 78 ] [ 9] [ 3]