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Protein Interactions;Outline;Molecular Interactions;Interaction Discovery;A measure of confidence?;High-throughput Mass Spectrometric Protein Complex Identification (HMS-PCI);Filtering;Lecture 4.1;Synthetic Genetic Interactions;Working overtime Charlie Boone’s Robots;Cell Polarity Cell Wall Maintenance Cell Structure Mitosis Chromosome Structure DNA Synthesis DNA Repair Unknown Others;PreBIND – Literature Mining;Search PreBIND with “Chk1”;View Possible Interactions;View the abstract;Lecture 4.1;Confirm and submit a BIND Interaction;Computational Interaction Prediction;Outline;Information Scope;A free, open-source database for archiving and exchanging molecular assembly information. BIND is managed by the Blueprint Initiative at Mount Sinai Hospital in Toronto. The database contains Interactions/Reactions Molecular complexes Pathways BIND has an extensive data model, GNU software tools and is based on the NCBI toolkit; extended recently to XML/Java The ~97000 BIND records are curated and validated.;Browse Interface (v2.5);BIND Submit Record View (v3.0);Publication Links;Ontoglyphs;Gene Ontology;BIND Interaction Viewer 3.0;Database of Interacting Proteins (DIP);DIP Search Interface;MINT;MINT Record View;MINT Interaction Viewer;Other Interaction Databases;Data Exchange File Formats;BIND;MINT – PSI level 1;PSI Record Format;BioPAX;Outline;Integrated Data Mining;Graph Theory;Useful Graph Operations;k-core;k-core;Spoke and Matrix Models;Graph Visualization;Graph Annotation Colouring;Stand-Alone Visualization Tools;Compare HMS-PCI to Other Large-scale Data Sets;Literature Benchmarks;Is HMS-PCI Better?;Another Large-scale MS Study;Comparing Data Sets;Ho vs. Gavin (spoke);Analysis of Combined Data Set;Pre MS;Outline;Systems Biology;Systems Biology;Space and Time resolved simulations;E-Cell;Systems Biology Workbench;Conclusion;+A2E5H8KcNfQiUlXp#s%v)y0B3F6I9LdOgSjVmYq!tw-z1D4G7JbMePhTkWoZr$u(x+A2E5H9KcNfRiUlXp#sv)y0C3F6IaLdPgSjVnYq!t*w-A1D4G8JbMeQhTkWoZr%u(x+B2E5H9KcOfRiUmX

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