奥美拉唑与胶体果胶铋治疗反流性食管炎的临床疗效对比.docVIP

奥美拉唑与胶体果胶铋治疗反流性食管炎的临床疗效对比 　　摘要：目的 对奥美拉唑与胶体果胶铋治疗反流性食管炎（RE）的临床效果进行对比分析。方法 选取我院2012年3月～2014年3月收治的120例反流性食管炎患者，通过随机数字表法分为甲组（n=60）和乙组（n=60），甲组患者给予奥美拉唑治疗，乙组患者采用胶体果胶铋治疗，观察和比较两组患者临床治疗效果。结果 甲组患者治疗总有效率90.00%，显著高于乙组78.33%，差异显著（P0.05）；甲组患者不良反应发生率6.67%低于乙组15.00%，但两组患者不良反应发生率比较差异无统计学意义（P0.05）。结论 在反流性食管炎治疗过程中，奥美拉唑与胶体果胶铋均能实现不错的临床效果，但奥美拉唑临床疗效相对优于胶体果胶铋，值得临床推广应用。 　　关键词：反流性食管炎；奥美拉唑；胶体果胶铋；临床效果 　　Abstract：Objective To analyze the clinical comparative effects of reflux esophagitis cured by omeprazole and colloidal bismuth pectin.Methods 120 patients who suffered from the reflux esophagitis and who accepted treatments in our hospital from March， 2012 to March， 2014 were taken as the research objects， and these patients were used random number table method randomly divided into the group A （n=60） and group B （n=60）. In the A group， they were treated with the omeprazole while in the B group， they were treated with the colloidal bismuth pectin.Then， the curing effects of these two groups of patients were compared and obseved. Results The response rate in the A group was 90.00%， which was evidently higher than that in the B group was 78.33%， and the differences was significant （P0.05）； In addition， the adverse reaction rate in the A group was 6.67% ，which was lower than that of B group was 15%， but two patients with adverse reaction rate had no significant difference （P0.05）.Conclusion In the course of reflux esophagitis treatment，omeprazole and colloidal bismuth pectin also can achieve good clinical effect， but the clinical effects of omeprazole is better than colloidal bismuth pectin，thus should be promoted in the clinical application. 　　Key words：Reflux esophagitis；Omeprazole；Colloidal bismuth pectin；Clinical effect 　　食管炎，又名食道炎，是由于多种因素刺激或损伤食管黏膜浅层或深层组织，引起食管黏膜水肿和充血的一种常见炎症[1]，包括化学刺激（药物、胃酸、烈酒、强碱等）和物理刺激（饮料、食物、食管异物等）；或患者机体抵抗力下降，结核杆菌、真菌或病毒感染引发食管炎，给患者生活、工作造成严重的影响。食管炎分为四种类型，即化脓性食管炎、放射性食管炎、急性腐蚀性食管炎和反流性食管炎。反流性食管炎（RE）是临床常见的食管炎，主要是指食管下端括约肌功能异常，胃或十二指肠小量内物反流入食管，造成食管黏膜炎性病变，临床表现为上腹疼痛、消化不良、反流、胸痛、烧心等，大大