肿瘤血栓临床研究.pptVIP

* In a mouse experimental model, the nadroparin dose (in anti-Xa units) required to inhibit lung metastases by 50% was five-fold lower than that of enoxaparin. The ability of heparins (UFH, nadroparin and enoxaparin) to inhibit P-selectin-dependent tumour cell interactions in vitro was positively correlated with their ability to inhibit experimental lung metastases in vivo. * * Breast cancer was more frequent in the Fraxiparine? group, whereas colorectal and cervical cancers were seen more often in the placebo group. A small proportion of patients did not have metastatic disease. The types