* Natural maintenance cycle and associated biological parameters for B. burgdorferi. (a) The spirochete is maintained in nature by alternating infections in white-footed mice and immature Ixodes ticks. Larvae (L) acquire spirochetes by feeding on infected mice and maintain the infection through the transstadial (TST) molt. Infected nymphs (N) transmit spirochetes during the next bloodmeal. (b) Spirochetes are exposed to alternating temperatures during tick and mammalian infections, and other parameters associated with tick attachment and feeding. (c) OspA and OspC are differentially expressed
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