快速蒙特卡洛模拟调强放疗剂量计算的研究-中国医学物理学杂志.PDF

第35 卷 第4 期 中国医学物理学杂志 Vol. 35 No.4 2018 年 4 月 Chinese Journal of Medical Physics April 2018 DOI: 10.3969/j.issn. 1005-202X.2018.04.003 医学放射物理 快速蒙特卡洛模拟调强放疗剂量计算的研究 杨耕，戴振晖，蔡春雅，李飞，张白霖，朱远湖，招什武，王学涛 广东省中医院放射治疗中心，广东广州510006 【摘 要】目的：提高蒙特卡洛模拟速度并应用于临床调强放疗剂量计算。方法：运用BEAMnrc 程序建立Varian_EDGE 加速器6 MV FF 与FFF 模式束流模型，在DOSXYZnrc 程序的基础上开发并行运算的Par-DOSXYZnrc（PDMC）剂量计算 程序，与SYNCJAWS、SYNCHDMLC 组件实现同步调强放疗剂量计算，并利用仿真模体和临床病例对该方法的精确性与 运算效率进行评估。结果：PDMC 与DOSXYZnrc 的剂量分布一致，与加速器测量值的偏差小于1%。PDMC 在6核处理 器中效率提升10.5 倍以上，能够在0.74 h 内完成调强放疗剂量计算，其效率随处理器核心数增加而增长。结论：建立的 PDMC 能保证临床调强放疗病例剂量计算的准确性，同时提高的效率可满足临床调强放疗剂量计算的时间需求。 【关键词】蒙特卡洛模拟；并行运算；剂量验证；调强放射治疗、 【中图分类号】R811.1 【文献标志码】A 【文章编号】1005-202X（2018）04-0384-05 Fast Monte Caro simulation for dose calculation in intensity-modulated radiotherapy YANG Geng, DAI Zhenhui, CAI Chunya, LI Fei, ZHANG Bailin, ZHU Yuanhu, ZHAO Shiwu, WANG Xuetao Department of Radiation Therapy, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510006, China Abstract:ObjectiveTo improve the speed of Monte Carlo simulation and apply it into the dose calculation in intensity-modulated radiotherapy (IMRT). MethodsVarian_EDGE linear accelerator 6 MV flattening filter and flattening filter free radiation source model were built with the use of BEAMnrc program. Then we developed a software-package PDMC with the foundation of DOSXYZnrc which is combined with SYNCJAWS and SYNCVMLC modules to achieve the synchronous IMRT dose calculation. Finally, the simulation phantoms and clinical cases were used to evaluate the accuracy and calculation efficiency of the proposed method. ResultsPDMC was in excellent agreement to DOSXYZnrc in terms of dose distributions, and the differ