己酮可可碱可降低性阻塞性肺气肿大鼠炎性反应.PDF

20 10 10 O ct. 2010 3 1 5 Journal of C ap italM ed ical U niversity V o l. 31 N o. 5 [ do:i 10. 3969/j. issn. 2010. 05. 002] 己酮可可碱可降低实验性阻塞性肺气肿大鼠炎性反应 * 陈阳育 张洪玉 庞宝森 李远红 ( ) ! ( p entox ifylline PTX ) W istar 36 ( : ) PTX ( 1 0. 5 h PTX 15 mg / kg 30 d) ; EL ISA ( TN F) 8 ( IL8) IL10 IL6IL8 HE : FEV0. 2 / FVC% ( P 0. 01) PTX FEV 0. 2 / FVC% (P 0. 01) : 3 IL8IL10TNF(P 0. 01) IL6(P 0. 0 1) CO PD PTX PTX ! ; ; ! R 364 Effects of Pentoxifylline on the Infla atory Reaction in Experi ental ObstructiveE physe aRatModels * CH EN Y angyu ZHANG H ongyu PANG B aosen L I Y u anhong (D ep artm ent of R esp iratory M ed ic ine, B e ij ing Chaoyang H osp ita ,l B eij ing Inst itute of R esp iratory M ed icine, Cap italM ed ical Un iv ersity ) ABSTRACT! Objective Pentox ify lline( PTX ) h as been show n to suppress the cytokine produc tion. Th is study ami ed to investigate the effect s of PTX on the produ ction o f pro inflamm atory cy tok ines and corre lation betw een the inflamm ation and ob stru ctive em physem a in ra t mode ls. M ethods T hirtysixW istar rats w ere random ly div ided in to 3 group s. ∀ N o rm a l g roup ( n = 12) rats w ere bred in canonical env ironm ent. # Ob stru ctive em physem a mode l g roup∃ ( n = 12) 3 m g / kg lipopo lysacch ar ide w as injected intravenou sly once every wt o w eek s and the rat s w e re exposed to 5% of cigarette sm oke 0. 5 h / each tmi e tw ice da ily for 45 days. % M ode l g roup ( n = 12) they w ere the sam e as tho se of ob stru ctive emphysem a m ode l g roup∃ but