课件：免疫学-1.ppt

* B.Anthracis 炭疽芽孢杆菌 The minimal structural requirement for peptidoglycan-mediated activation of NOD2 is muramyl dipeptide, which is present in both Gram-positive and Gram-negative bacteria. Muramyl dipeptide can be released through the action of bacterial hydrolases during cell-wall biosynthesis and remodelling, or after degradation of ingested bacteria by host lysozyme. * muramic acid：胞壁酸 NOD1 recognises diamino-pimelate containing moieties found in the peptidoglycan structure from Gram-negative bacteria. NOD2 recognises muramyl dipeptide, a ubiquitous structure common to the peptidoglycan