化学药实用工艺研究Practical-Process-Research-and-Development.pptxVIP

Practical Process Research and Development;Content：;1 Route Slection;1-1: Analyzing Waste Streams (First Principle);Routes with fewer steps require smaller quantities of starting materials, solvents, and reagents, and require less labor.;1-2: Atom EconomyAtom economy is not the primary consideration for manufacturing in the pharmaceutical industry;Example ;Biotransformations;Example;Example:;Guidelines for developing biocatalytic processs;Cost estimates;2 Reagent Selection;Some ideal characteristics of reagents;2-1 Strong bases;Kot-Bu is a moderately strong base, and its use on scale can be h