放射性核素标记Exendin-4类似物用于胰岛素瘤显像的-肿瘤防治研究.PDFVIP

2015 42 4 Cancer Res Prev Treat,2015,Vol.42,No.4 407 肿瘤防治研究 年第 卷第 期 · · doi:10.3971/j.issn.1000-8578.2015.04.020 ·综    述· 放射性核素标记Exendin-4类似物用于 胰岛素瘤显像的研究进展 1 2 1,2 许清 ，杨敏 ，罗世能 Recent Advances in Radionuclide-labeled Analogues of Exendin-4 for Insulinoma Imaging XU Qing1 2 1,2 , YANG Min , LUO Shineng 1. Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029,China; 2. Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China Corresponding Author: LUO Shineng, E-mail: luoshineng@jsinm.org Abstract: Insulinoma is one of the most common pancreatic endocrine neoplasm and is difficult to be detected by typical technology. Radionuclide imaging methods such as SPECT and PET have provided a new technology for insulinoma diagnosis with advantages of non-invasive, high sensitivity and specificity. Glucagon-like peptide-1 receptor(GLP-1R) is an attractive target for imaging due to its overexpression in insulinoma. Exendin-4, the agonist of GLP-1R, could specifically bind to the receptor. This paper reviews the progress of radionuclide-labeled Exendin-4 analogs in insulinoma imaging. Key words: Radionuclide; Glucagon-like peptide-1 receptor(GLP-1R); Exendin-4; Radionuclide imaging 摘  要：胰岛素瘤是常见的胰腺内分泌肿瘤，常规方法难以检测。核素显像如单光子断层扫描 SPECT PET （ ）和正电子断层扫描（ ）具有无创、敏感度高、特异性好等优势，为胰岛素瘤的诊 -1 GLP-1R 断提供了新技术。胰高血糖素样肽 受体（ ）在胰岛素瘤中高表达，是潜在的肿瘤靶点。 Exendin-4作为GLP-1R激动剂，可与受体特异性结合。本文介绍放射性核素标记GLP-1R激动剂 Exendin-4 （ ）类似物的进展及在胰岛素瘤显像研究中的应用。