某权威高校教学幻灯内容丰富图文并茂推荐模板细胞和分子免疫学.pptVIP

1994 Polly Matzinger APCs are activated by endogenous cellular alarm signals from distressed or injured cells Distressed cell Normal cell The Danger Model the “foreignness” of a pathogen is not the important feature that trigers a response, and “self-ness” is no guarantee of tolerance. 免疫学的几个基本问题 克隆选择 Clonal selection Sir FM Burnet (1899-1985) The Self-Nonself Models The Self-Nonself Model Burnet’s original model Different parts of the variable regions of antigen receptors are encoded by sets of gene segments. The rearranged genes are expressed to produce the two types of polypept