高磁响应性fe30号4@功能聚合物核-壳亚微球的合成.docxVIP

摘要摘要 摘要 摘要 磁性多功能微纳米复合微球在生物医学和分离分析技术等领域有着广泛的 应用，一直受到研究人员的广泛关注。包裹Fe304磁性纳米粒子的非均相聚合是 制备这类复合微球的传统方法，但由此得到磁性聚合物微球一般磁含量较低， 磁响应速度慢，形态可控性较差，限制了其应用范围。近年来，有研究人员报 道了由溶剂热法一步合成由多个Fe304磁性纳米粒子构成的单分散超顺磁性磁簇 粒子。这种类石榴结构的磁簇粒子的尺度在数十纳米至数百微米范围内可控， 具有很好的磁响应性，以此为核构建核壳复合微球可望克服上述方法的不足。 为此，本文通过溶剂热法合成表面富含羧酸根的Fe304磁簇粒子，在此基础上研 究了两种高磁响应性Fe304@功能聚合物核．壳亚微球的合成。主要工作如下： 1．基于功能单体或交联单体与Fe304磁簇粒子表面的羧酸根离子之间的氢键 作用，通过表面沉淀聚合制备具有不同功能基团的Fe304@交联聚合物核．壳亚微 球。考察的功能单体包括Ⅳ．异丙基丙烯酰胺(N姒)、甲基丙烯酸(MAA)、甲 基丙烯酸．2．羟乙酯(HEMA)、4-乙烯基吡啶(4-VPy)，交联剂为Ⅳ．Ⅳ-亚甲基双 丙烯酰胺(MBA)。还合成T Fe304@}Si02微球及表面修饰双键的Fe304@ISi02微球， 在其表面包裹聚合物层。 2．壳聚糖(CS)是具有良好生物相容性的天然高分子，其分子结构中富含 氨基和羟基。基于CS与Fe304磁簇粒子的表面羧基及丙烯酸(从)之间的相互 作用，合成T Fe304@(CS．PAA)微球及Fe304@CS微球，对磁性聚合物微球进行了 TEM、SEM、XRD、TG、VSM、DLS等表征。 关键词：高磁响应磁簇粒子功能聚合物核壳结构磁性聚合物微球 AbstractAbstract Abstract Abstract The multifunctional magnetic nanocomposites materials have received a great deal of attention because of their wide applications in many fields，such aS biological medicine，separation science,and SO on．The heterogeneous polymerization is the traditional method to prepare the magnetic mierospheres coating the Fe304 nanoparticles，however,the magnetic polymer microspheres obtained from this polymerization have some disadvantages with a low magnetization and the poor controllable morphology,which hampers meir applications extremely in bio—related fields．In recent years，the researchers reported a one—step reaction to synthesize the monodisperse superparamagnetic microclusters which composed of many iron oxides by a solvothermal reaction．The structure of this magnetite particles is similar in appearance to a pomegranate，and the particle size WaS tunable in the range of tens and hundreds of nanomcters．The core-shell composite microsphercs in the presence of highly performance magnetic microclusters as core are expected to overcome the deficiencies described above．Based on the fact，we prepared the monodisperse highly magnetic polymer microspheres with the iron oxide magnetic dusters as core obtained by a modified solvoth