卫氏并殖吸虫.ppt

Morphology Adult worm Flattened (flatworm) and leaf like Sucker: oral sucker 口吸盘 ventral sucker腹吸盘 Digestive tract: not intact (消化道不完整） i.e. no anal opening肛门, caecum盲肠 Reproductive system: hermaphrodite 雌雄同体 exception of schistosome Life Cycle Complex Alteration of generation 世代交替sexual generation and asexual generation alter in the life cycle of parasite Asexual multiplication in larval stage in snail螺蛳host Multiple hosts transfer and having reservoir hosts Water environment is essential Important Species Liver fluke: Clonorchis sinensis Intestinal fluke: Fasciolopsis buski Lung fluke: Paragonimous westermani P. skrjabini Blood fluke: Schistosoma spp. 华支睾吸虫 Clonorchis sinensis 寄生肝胆管 致肝吸虫病clonorchiasis ，主要分布远东地区 人体感染与饮食习惯有关 人体首例1874;国内1908上海 Morphology（Adult） 大小、体形似葵花子 口吸盘略大于腹吸盘 睾丸分支，卵巢分叶 Morphology（Egg） 蠕虫卵中之最小者 形似芝麻，具卵盖、肩峰， 另一端有小棘，内含毛蚴 Life cycle 成虫 Main points of Life cycle 成虫寄生肝胆道 经粪便排出虫卵 需2个中间宿主：豆螺、淡水鱼 经口吞食鱼虾中囊蚴感染 猫,狗,猪等为重要储蓄宿主 The second intermediate host of C.sinensis 淡水鲤鱼科类； 野生小型鱼类如麦穗鱼（Pseudorosbora ? parva）感染率较高 Pathogenesis 成虫为主要致病阶段 机械及毒素致胆管炎症、黄疸、结石 重症慢性感染可导致肝纤维化、肝癌 Pathogenesis Pathogenesis 肝硬化腹水 肝吸虫病人（图中） Laboratory Diagnosis 病原学诊断 粪检查卵：沉淀法 sedimentation method 十二指肠引流液查卵 duodenal aspiration 免疫学诊断： ELISA to detect antiboby or antigen 其它：询问病史（食生鱼史） Epidemiology Distribution Far East(China, South Korea, Japan, etc.) 24 provinces in China(Guangdon: 5 million infected etc.) Endemic Factors Source of infection: mainly wild carnivoresr肉食动物 I,II intermediate host in the same water-field Mode of fish breeding Dinning habit Custom Principle of Control Cure patients carrier praziquantel吡喹酮:25mg/kg, tid, 2 days Control reservoir host Carry out scientific fish-breeding Hygienic education not eating raw or undercooked fishes 卫氏并殖吸虫 Paragonimus westermani 概 述 人兽共患、兽主人次 世界性分布 成虫寄生于肺，致肺部病变 亦可异位寄生于脑，皮下等 成虫形态 肥厚、背部隆起似半粒黄豆 鳞状皮棘(利于组织内穿行) 生殖腺并列 口腹吸盘大小略同 虫卵特征 不规则椭圆形,金黄色 有宽而扁平的卵盖 内含卵细胞和卵