青年和绝经后女性乳腺癌c2erbB22、p53、ER和PR受体表达.PDFVIP

肿瘤防治研究 2004 年第 31 卷第 2 期 ·97 · 青年和绝经后女性乳腺癌 cerbB2 、p53 、ER 和 PR 受体表达及意义 1 2 3 3 1 张 　英 ,刘永源 ,黄应桂 ,郑朝晖 ,梁启廉 Expressionofc erbB2 、p53 、ERandPRbetweentheYoun gand PostmenopausalWomenWithBreastCancer ZHANGYin g,LIUYon gyuan,HUANGYin ggui,etal Department of Medical Oncolo gy , Af filiated Hospital of Guan gdon g Medical College , Zhanjin g 524001 , China Abstract:Objective 　Tostud ytheex pressionofc erbB2 、p53 、ERandPRbetween youngand postmenopausal womenwithbreastcancer. Methods　Theex pressionofc erbB2 、p53 、ERandPRin131 youngwomenand 136Postmeno pausalwomenwithbreastcancerwerestudiedb yS Pimmunohistochemistr y,withitsrelation withclinicalTNMsta ge 、axillaryl ymphnode (ALN ) metastasisand3 yeardisease-freesurvival (DFS) . Re sults 　Theex pressionofc erbB2correlatedwithclinicalTNMsta gesandALNmetastasis ( P 0.05 ) .The3 yearDFSofc erbB2 positivelywaslowerthanc erbB2ne gatively ( P 0.05 ) .The positiverateofCerbB 2 and p53werehi gherandThe positiverateofERwaslowerinthe young group ( P 0.01 ) .3 yearDFSofthe young groupwaslowerthan postmenopausal group ( P 0.05 ) . Conclusion　cerbB2isanim portant parame teron pro gnosisofbreastcancer.The positiveratesofc erbB2and p53werehi gh.The positiverateofER andthe3 yearDFSwerealsolowinthe youngwomen,and poor pro gnosisinthe youngwomen 。 Keywords: Breastcancer;c erbB2; p53;ER;PR 摘 　要 : 目的　探讨青年和绝经后女性乳癌 cerbB2 、p53 、ER 、PR 的表达及意义 。方法 　采用 SP 法检 ( ) ( ) ( ) 测青年组 131 例 与绝经组 136 例 乳癌组织中各指标的表达及其与临床分期 、腋淋巴结 ALN 转移 、3 ( ) ( ) 年无病生存率 DFS 之间的关系 。结果 　cerbB2 阳性与临床分期 、ALN 转移相关 P 0.05 ,cerb