合并高脂血症的胃癌患者PGE2VEGF表达水平和临床-中国肿瘤临床.PDF

中国肿瘤临床2016年第43卷第19期 ChinJClinOncol2016.Vol.43.No.19 845 临床研究与应用 · · 合并高脂血症的胃癌患者PGE2 VEGF表达水平和临床病理特征的相关研究 张骜 刘嘉 黄飞 周扬 李卫东 付蔚华 刘彤 摘要 目的：比较合并高脂血症的胃癌患者与未合并高脂血症患者的血清前列腺素E2（ptodyshlsnfinE2，PGE2）、血清血管内皮生 长因子（voscularendothelialgrowthfactor，VEGF）水平、胃癌组织VEGF表达水平和肿瘤临床病理特征的差异，探讨高脂血症对胃 癌进展的影响。方法：将全部天津医科大学总医院2014年3月至2014年12月102例胃癌患者分为两组，合并高脂血症患者组49 例，不合并高脂血症患者组53例。应用酶联免疫吸附测定法及免疫组织化学法测定102例胃癌患者血清PGE2、VEGF的浓度及 肿瘤组织中VEGF的表达水平。结果：与不合并高脂血症的患者相比，合并高脂血症的胃癌患者，其血清PGE2、VEGF浓度以及 胃癌组织中VEGF的表达水平均有明显升高（P0.05）；且胃癌组织分化程度、浸润深度、淋巴结转移枚数、TNM分期差异均具有统 计学意义（P0.05）。结论：合并高脂血症的胃癌患者可能通过上调PGE2和VEGF的表达促进胃癌的进展。 关键词 胃癌 高脂血症 前列腺素E2 血管内皮生长因子 临床病理特征 doi:10.3969/j.issn.1000-8179.2016.19.843 Association of serum PGE-2 and VEGF levels and the expression of VEGF in gastric can- cer tissue and clinicopathological features of gastric carcinoma patients with hyperlip- idemia Ao ZHANG, Jia LIU, Fei HUANG, Yang ZHOU, Weidong LI, Weihua FU, Tong LIU Correspondence to: Tong LIU; Email: liutonga@126.com Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China Abstract Objective: This study aims to compare the difference in the expression levels of prostaglandin E2 (PGE2), vascular endotheli- al growth factor (VEGF), and the clinicopathological features among gastric carcinoma patients with and without hyperlipidemia and to assess whether hyperlipidemia promotes gastric carcinoma progression. Methods: We analyzed the PGE2 and VEGF serum levels and the VEGF expression in gastric carcinoma tissues in 102 gastric carcinoma patients. The PGE2 and VEGF serum levels were detected by enzyme-linked immunosorbent assay, and the VEGF expression in gastric carcinoma tissues was detected by SABC immunohistochemi- cal staining. Results: Among the 102 gastric c