课件第a10讲 RNA二级结构预测.pptVIP

Refers: Washietl, Hofacker, Stadler. “Fast and reliable prediction of noncoding RNAs.” Proceedings of the National Academy of Sciences, USA, 2005, 102: 2454-2459. Eddy. “Computational Genomics of Noncoding RNA Genes.” Cell, 2002, 109: 137-140. Biological significance Drug targets microRNA Other non-coding RNAs 第10讲 Predicting RNA Secondary Structure David Mathews (David Mathews.pdf) Outline: What is RNA secondary structure? Gibbs free energy change. Predicting free energy changes for RNA helices. Predicting RNA secondary structure by free energy minimization. Hierarchi