logo

您所在位置网站首页 > 海量文档  > 医学 > 医学

红细胞生理学英文.ppt 43页

本文档一共被下载: ,您可全文免费在线阅读后下载本文档。

  • 支付并下载
  • 收藏该文档
  • 百度一下本文档
  • 修改文档简介
全屏预览

下载提示

1.本站不保证该用户上传的文档完整性,不预览、不比对内容而直接下载产生的反悔问题本站不予受理。
2.该文档所得收入(下载+内容+预览三)归上传者、原创者。
3.登录后可充值,立即自动返金币,充值渠道很便利
特别说明: 下载前务必先预览,自己验证一下是不是你要下载的文档。
  • 上传作者 word文档(上传创作收益人)
  • 发布时间:2019-07-11
  • 需要金币280(10金币=人民币1元)
  • 浏览人气
  • 下载次数
  • 收藏次数
  • 文件大小:6.45 MB
下载过该文档的会员
你可能关注的文档:
* * * * * * * * * * * * * Hereditary Iron Overload “Hemochromatosis” Heterogeneous group of inherited disorders representing mutations of genes which control iron absorption and storage Iron accumulates in liver, heart, pancreas, joints, gonads; clinical manifestations seen earlier in men Treated with phlebotomy to remove iron-rich RBCs Mutations: HFE (most common), TfR2, hemojuvelin, hepcidin and ferroportin genes Hemoglobin switch Taken from C.Shanmuganathan and D. Kamat. Pediatric Annals 2013;42:12:502-508 Hgb A = α 2 β 2 Hgb F = α 2 γ 2 Hgb A2= α 2 δ 2 Hemoglobin Structure-Function relationships/1 Modified from Dean & Schechter: NEJM, 299:752-763, 1978 by Babior & Stossel: Hematology: A Pathophysiologic Approach, Churchill Livingstone, 1994, pg. 28. Erslev & Gabuzda,eds.Pathophysiology of Blood, Philadelphia: W.B. Saunders, 1975, pg. 17. Hemoglobin Structure-Function Relationships/2 26.6 RBC Membrane Lipid Composition (/Pages/500/520/520, html. Downloaded 07/22/2013, Oakland Children’s Hospital Medical Center.) RBC Membrane Schematic Structure Modified from Molecular Medicine?. Copyright, Daniele Focosi 2001-2013. Updated weekly. Available at . Accessed 7/17/13. 4.1 Modified from Hillman & Finch: Red Cell Manual, 5th ed. F.A.DavisCo., 1985, pg. 14. Elimination of peroxides; Protection against oxidants ADP ATP ADP ATP RBC Metabolism Requirements ATP for energy to maintain membrane integrity, water content, and deformability NADH to maintain reduced heme Fe 2,3 DPG for enhanced 02 release under conditions of low tissue 02 tension NADPH to facilitate removal of toxic oxidants and prevent denaturation of globin The Aging RBC Young RBC Senescent RBCs Day 120 Day 7 Recycling of RBC Components Protoporphyrin ring broken, releasing CO, tetrapyrrole and Fe Unconjugated bilirubin bound to albumin transported to liver for conjugation In the gut, conjugated bilirubin is converted to urobilinogen which is excreted in stool or reabsorbed and excreted by the

发表评论

请自觉遵守互联网相关的政策法规,严禁发布色情、暴力、反动的言论。
用户名: 验证码: 点击我更换图片

“原创力文档”前称为“文档投稿赚钱网”,本站为“文档C2C交易模式”,即用户上传的文档直接卖给(下载)用户,本站只是中间服务平台,本站所有文档下载所得的收益归上传人(含作者)所有【成交的100%(原创)】。原创力文档是网络服务平台方,若您的权利被侵害,侵权客服QQ:3005833200 电话:19940600175 欢迎举报,上传者QQ群:784321556