Glucose clamp technique a method for quantifying insulin secretion and resisitance英文学习资料 .pdfVIP

Glucose clamp technique: a method for quantifying insulin secretion and resistance RALPH A. DEFRONZO, JORDAN D. TOBIN, AND REUBIN ANDRES Department of Medicine, Yale Un, lersity School of Medicine, New Haven, Connecticut 06510; and Clinical Physiology Branch, Gerontology Research Center, National Institute of Aging, Baltimore City Hospitals, Baltimore, Maryland 20014 DEFPIONZO, RALPH A., JORDAN D. TOBIN, AND REUBIN at times the absolute I and G concentrations are used, ANDRES. Glucose clamp technique: a method for quantifying but the increases in these concentrations over basal levels insulin secretion and resistance. Am. J. Physiol. 237(3): E214- have also been used. The use of this index carries the E223, 1979 or Am. J. Physiol.: Endocrinol. Metab. Gastrointest. assumptions that 1) at any moment the plasma insulin Physiol. 6(3): E214--E223, 1979.-Methods for the quantifica- concentration reflects the response to that moment’s tion of beta-cell sensitivity to glucose (hyperglycemic clamp plasma glucose concentration and 2) this dose-response technique) and of tissue sensitivity to insulin (euglycemic in- sulin clamp technique) are described. Hyperglycemic clamp relationship is a simple linear one. technique. The plasma glucose concentration is acutely raised The same data