妊娠期高血压疾病患者凝血功能及D二聚体水平检测的临床意义.docxVIP

妊娠期高血压疾病患者凝血功能及D—二聚体水平检测的临床 意义 【摘要】目的分析妊娠期高血压疾病患者凝血功能及D-- 聚体(D-D)水平检测的临床意义。方法 选择50例妊娠期高血 压疾病患者为实验组，另将同期收治的50例健康妊娠孕妇设置 为常规组，对比两组的凝血功能及D-二聚体水平。结果 实验 组的凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶 时间(APTT)分别为(13?86±2?85)、( 10. 22±2? 55)、(27. 84 ±5. 98)s,明显低于常规组的(15. 88±3. 21)、(12. 56±2. 68)、 (31?85±6?21) s；实验组D-二聚体与纤维蛋白原(FIB)分别 为(1.85 + 0. 62) mg/L、(4. 68±1. 24) g/L,明显高于常规组的(1. 32 ±0. 46)mg/L、(3? 74+1. 20)g/L；差异均有统计学意义(P〈0? 05)。 结论进行D-二聚体与凝血功能指标水平检测的临床意义重大, 可及时发现妊娠期高血压疾病患者凝血功能异常情况与高血压 疾病，从而指导疾病的治疗。 【关键词】妊娠期高血压；凝血功能；D-二聚体；检测 D0I： 10. 14163/j. cnki. 11-5547/r. 2017. 0 016 【Abstract 1 Objective To analyze the clinical significance of coagulation function and D-dimer (D~D) level detection in gestational hypertension patients? Methods There were 50 gestational hypertension patients as experimental group , and concurrent 50 healthy pregnancy women as conventional group? Comparison were made on coagulation function and D-dimer level in two groups? Results The experimental group had thrombin time (TT ) , prothrombin time ( PT ) , activated partial thromboplastin time (APTT) respectively as (13?86± 2. 85), (10. 22土2.55) and (27. 84 + 5. 98) s, which were obviously lower than (15. 88±3? 21), (12. 56±2. 68) and (31 ? 85±6? 21) s in conventional group? The experimental group had D-dimer and fibrinogen (FIB) respectively as (1.85±0.62) mg/L and (4. 68± 1. 24) g/L, which were obviously higher than ( 1.32 + 0. 46 ) mg/L and ( 3. 74 + 1. 20 ) g/L in conventional group, and their difference had statistical significance ( P0.05 ) ? Conclusion Detection of coagulation function and D-dimer level shows grea t clinical significance, and it can timely finds coagulant function abnormality and hypertension disease in gestational hypertension patients to guide the treatment of disease. function； D-dimer； Detection 妊娠期高血壓属于妊娠期间的一类疾病，可对母婴健康造 成严重的危害，发生率达到10%左右［1］,以高血压、蛋白尿、 水肿［2］等作为主要的临床症状，更有甚者将出现昏迷、抽搐、 脏器功能衰竭等不良情况，目前临床上对该类疾病的具体发病 机制仍然无明确的定论［3］。而正常妊娠孕妇血液常常处于高凝 状态与生理性贫血状态，若出现妊娠期高血压疾病时，将使得 凝血激活增强［4］。许多临床研究指出，妊娠期高血