毕业论文-- 血清降钙素原对脓毒症的诊断价值.docVIP

本科生毕业论文填报表 院 （系） 学 科、 专 业 论 文 题 目 血清降钙素原对脓毒症的诊断价值 指 导 教 师 申 请 者 姓 名 目录 中、英文摘要………………………………………………３ 引言、资料与方法…………………………………………4 结果…………………………………………………………5 讨论…………………………………………………………7 参考文献……………………………………………………8 致谢…………………………………………………………8 血清降钙素原对脓毒症的诊断价值 摘要：目的：通过测定脓毒症患者血清降钙素原（PCT），c-反应蛋白（CRP）水平，并行APACHEⅡ评分（急性生理与慢性健康状况评分），比较二者与该评分之间的相关性，进一步探讨降钙素原在诊断脓毒症方面的价值。 方法：选择2014年9月至2015年3月入住我院重症监护病房(ICU)的脓毒症患者100例，按感染程度（由轻到重）分为三组：脓毒症组，严重脓毒症组，脓毒症休克组，同时选择同期入住我院普通病房的非脓毒症患者20例作为对照组，检测其血清降钙素原,c-反应蛋白水平及APACHEⅡ评分，进行对比分析。结果：脓毒症组，严重脓毒症组，脓毒症休克组的血清降钙素原，c-反应蛋白水平和APACHEⅡ评分均高于非脓毒症组，差异有统计学意义（P0.05）;脓毒症组血清降钙素原水平、APACHEⅡ评分随感染程度的升高而升高，差异有统计学意义（P0.05）,而血清c-反应蛋白水平差异无统计学意义（P0.05）;血清降钙素原水平与APACHEⅡ评分之间呈显著正相关（r＝0.68，P0.05）,而血清c-反应蛋白水平和APACHEⅡ评分之间无相关性（P0.05）。结论：血清降钙素原对脓毒症的诊断价值优于c-反应蛋白。 关键词：降钙素原；c-反应蛋白；APACHEⅡ评分；脓毒症 Abstract： Abstract：Objective: Through the determination of sepsis patients serum procalcitonin (PCT), C-reactive protein (CRP) levels, parallel APACHE II score, correlation between the compared with the score, to further explore the value of PCT in the diagnosis of sepsis. Methods: 100 cases of patients with sepsis in September 2014 to 2015 3 month stay in our hospital intensive care unit (ICU), according to the degree of infection (from light to heavy) divided into three groups: sepsis group and severe sepsis sepsis group, purulent septic shock group, and stay in the same period in our hospital general ward patients without sepsis in 20 cases as the control group, serum calcitonin angiotensinogen, C-reactive protein level and APACHE II score, were compared and analyzed. Results: sepsis sepsis group, severe sepsis sepsis group and septic shock syndrome group of serum calcitonin gene-related peptide, C-reactive protein levels and APACHE II scores were higher than those in non sepsis group, the difference was statistically significant (P 0.05);