小剂量阿昔洛韦治疗玫瑰糠疹54例疗效观察.docx

小剂量阿昔洛韦治疗玫瑰糠疹54例疗效观察 李伟权周秀莲陈宏辉胡婷 （广东省粤北人民医院广东韶关512026） 【摘要】目的：比较阿昔洛韦和对照组治疗玫瑰糠疹的疗效。方法：门诊 57例玫瑰糠疹患者，随机分为阿昔洛韦治疗组（400毫克，一日三次，共1周） 和对照组，观察4周。其中54例完成观察。每周观察记录患者皮肤红斑及脱屑 改善情况。结果：经统计分析，阿昔洛韦组红斑消退在治疗后第1234周均优 于对照组。阿昔洛韦治疗组脱屑症状在治疗后第123周较对照组消退明显，但 第4周两组无统计学差异。结论：我们的研究表明，小剂量阿昔洛韦治疗玫瑰糠 疹，红斑脱屑症状消退较对照组更快，能缩短病程。推荐该方法用于治疗玫瑰糠 疹，尤其是皮疹广泛或伴有瘙痒患者。 【关键词】玫瑰糠疹阿昔洛韦红斑鳞屑病程 【中图分类号】R969.4 【文献标识码】A 【文章编号】2095-1752 （2014） 13-0155-02 Treatment of pityriasis rosea with low dose of acyclovir: a clinical trail on 54 pationts [Abstract ] Objective The aim of this study was to campare acyclovir with control protocol for the treatment of pityriasis rosea.Methods A randomized, camparative, 4-weeks study was designed. Fifty-seven pationts with PR presentJng at the outpatie nt clinic were rand only allocated to acyclovir or con trol group. Fifty-four of them completed the period of study and their clinical responses such as improveme nt rate of erythema,a nd scali ng .Results Statistically, acyclovir was more effective than control in reducing erythema at the end of the first ,second,third and fourth week of treatment. Although the derease in scaling was higher in the acyclovir group at the end of the first ,second,third week of treatment, there was no statistical sign讦icance between two groups at the end of fourth week of treatment .Conclusions According to our study, acyclovir may be more effective than control in reducing erythema and shortening of duration of PR even in lower doses than was applied in previous studies ? We suggest to consider this treatme nt whe n facing a patio nt suffering from this problem, At least in extensive or with pruritus ones. ［Keywords］ Pityriasis rosea acyclovir duration erythema scaling 玫瑰糠疹（pityriasis rosea, PR）是一种常见的自限性炎症性皮肤病。已有研 究表明，PR可能与人类疱疹病毒7（HHV?7）被激活有关，少数情况下可能是人类 疱疹病毒6（HHV-6）被激活［1?5］。除了给患者提供该病的必要知识，消除患者顾 虑，多数症状较轻的患者不需要系统治疗。有些患者皮疹广泛或者伴有明显瘙痒, 则需要系统治疗。近来，Drago等用大剂量阿昔洛韦（800毫克，一天5次，疗程 1周）治疗PR,结果表明可以缩短皮疹清除吋间。由于大剂量阿昔洛韦方案在临 床实际操作中比较困难，患者依从性差，因此我们设计了小剂量阿昔洛韦治疗 PR随机对照试验，观察其临床疗效。