* * When monitoring a container system supplied by the medical device manufacturer that has many levels, place two chemical indicators in opposite corners on each level. Each level creates a different challenge to air removal and steam penetration especially when there are different types of boxes and containment devices on each level. * To verify these product changes, place multiple biological and chemical indicators into packages into the areas considered the greatest challenge. If the Medical device manufacturer does not provide that information then consider corners and all different
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