老化与抗氧化能力及其相关分子检测.ppt

老化與抗氧化能力及其相關分子檢測 Dr.曾婉芳 Oxidative stress Oxidative Stress Reactive oxygen species (ROS) ROS and oxidative stress Antioxidant system Oxidative damage Oxidative stress and apoptosis Oxidative stress and aging Oxidative stress and cancer ROS as signaling molecules Reactive oxygen species (ROS) ROS OH. (hyroxyl radical) O2-. (superoxide radical) H2O2 (hydrogen peroxide) NO. (nitric oxide) Oxidative stress Oxidative damage Toxic effects of ROS Protein oxidation Lipid peroxidation Nucleic acids damage Double-strand DNA breaks Single-strand DNA breaks Change DNA bases 8-oxoguanine Thymine glycol Lip