因心血管不良反应撤的药物情况分析-中国药房.PDF

因心血管不良反应撤市的药物情况分析 ＊ 毛 璐 ，高 杰（北京积水潭医院药剂科，北京 100035） 中图分类号 R969.3；R952 文献标志码 B 文章编号 1001-0408（2013）06-0560-05 DOI 10.6039/j.issn. 1001-0408.2013.06.31 摘 要 目的：调查近年来因心血管不良反应撤市的药品情况，总结其引发心血管不良反应的特点，为临床合理使用药物提供借 鉴。方法：检索国内外文献数据库及互联网，收集近年来因引起心血管不良反应而撤市的药物及其相关信息，并进行总结。结果： 近年来在国内外因心血管事件撤市的药品涉及非甾体抗炎药、减肥药、抗组胺药等十余品种。结论：临床应警惕药物的心血管不 良反应，规范用药剂量及合并药物，提高临床用药的有效性和安全性。 关键词 心血管不良反应；撤市；分析 Analysis of Withdrawn Drugs Because of Cardiovascular Adverse Reactions MAO Lu ，GAO Jie（Dept. of Pharmacy ，Beijing Jishuitan Hospital ，Beijing 100035，China ） ABSTRACT OBJECTIVE ：To investigate the drugs withdrawn from the market because of cardiovascular adverse reactions in recent years ，and to sum up the characteristics leading to cardiovascular adverse reactions and provide reference for rational use of drugs in the clinic. METHODS ：Retrieved from domestic and foreign literature databases and the Internet ，the data of drugs withdrawn from the market because of cardiovascular adverse reactions and related information were collected and summarized in recent years. RESULTS ：In recent years because of cardiovascular events ，more than ten drugs were withdrawn ，involving non-steroidal anti-inflammatory drugs ，diet pills ，anti-histamine ，etc. CONCLUSION ：The cardiovascular adverse drug reactions should be noticed. The dosage and combined use of drugs should be standardized ，in order to improve the safety and effectiveness of clinical medication. KEY WORDS Cardiovascular adverse reaction ；Withdraw ；Analysis 药物，每日剂量1次给予，疗效增强。但由于甲硝唑不良反应 外用（膀胱冲洗），增加细菌耐药性；盐酸莫西沙星或哌拉西林/ 常见，有15％～30％的病例出现不良反应，以消化道反应最为 他唑巴坦联用硝基咪唑类抗菌药物，前2种抗菌药物对厌氧菌 常见，包括恶心、呕吐、食欲不振、腹部绞痛；另有神经系统症 有抗菌作用，此种联用属抗菌谱部分重叠。甲硝唑属浓度依赖 状、荨麻疹、排尿困难、口中金属味及白细胞减少等。因此建议 型抗菌药物，每日剂量1次给予，疗效增强；但由于甲硝唑不良