T细胞亚群及记忆细胞课件.ppt

Discovery of Suppressor T cells CD4+CD25+Tr cells CD4+CD25+Tr cells Constitutively express the IL-2R-α (CD25) Glucocorticoid induced tumor necrosis factor receptor (GITP) 5-10% of the peripheral T cell pool The regulatory effect by a mechanism dependant on cell-cell contact Expression of the inhibitory co-stimulatory molecule CTL-4 Cell surface TGF-β or release IL-10 Foxp3, master regulatory gene Overview of phenotypes and functions of CD4+ T cells Na?ve CD4 Th1 Tr Th2 IFN-γ Cell mediated immune responses IL-4 IL-5 IL-10 IL-13 humoral immune response Tr 1 Th 3 CD4+ CD25+ High IL-10 , low TGF-β TGF-β cell-cell contact Natural Tr in thymus contact-dependent Adaptive Tr in peripheral lymphoid tissue cytokines-dependant Regulatory T cells Differentiation of Tr cells Na?ve CD4+ T cells Tr1 Th3 CD4+CD25 TGF-β TGF-β IL-10 + IFN-α _ Primary function of Tr cells Maintaining self-tolerance and homeostasis Preventing infection-induced immunopathology Prolong pathogen persistence by suppressing protective Th1 responses Generation of Tr1 cells OVA-TCR Na?ve CD4 Tr1 cells IL-10 IL-5 +TGF-β OVA + IL-10 Immunosuppressive drugs Anti-IL-4 + Anti-IL-12 Phenotype and function of Tr 1 cells Expression CCR5 and TS-STL Immunosuppressive properties: - prevent the development of Th1 mediated autoimmune disease - suppress immune response to pathogens, tumors and allo antigens - suppress of proliferative responses and cytokine production The suppressive effects of Tr1 cells are reversed by neutralizing IL-10 Th3 cells Secrete TGF-β Suppress the induction of experiment autoimmune encephalomyelitis (EAE). Suppress the induction of protective tumor-specific cytotoxin T lymphocyte (CTL) responses Th22细胞 一个德、英、意联合研究小组日前发现了一种被称为Th22的免疫细胞，这种细胞处于“失控”状态，可加剧皮肤、新陈代谢以及呼吸系统等方面的慢性炎症。 　　德国亥姆霍兹慕尼黑中心2009年11月18日发布公报说，Th22细胞是T辅助细胞的一个亚群。T辅助细胞也是免疫细胞，能在病毒或病原体侵入肌体时帮助激活其他免疫细胞。它还能控制肌体的发炎反应，以抵御病毒