原创力文档- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
查看更多
各种免疫抑制剂毒副作用 CSA FK RPM Pred Aza MZ MMF 肾毒性 ++ + — ？ — — — 肝毒性 ++ + — — + — — 骨髓抑制 — — ± — + — + 高血压 ++ + — + — — — 高血脂 ++ + +++ + — — — 高血糖 + ++ — + — — — 高尿酸 — — — — + ++ + 神经毒 + + ? — — — — 骨质疏松 + + — ++ — — — 狼疮性肾炎的治疗小结1 肾上腺皮质激素单独或与免疫抑制药物合用是治疗狼疮性肾炎的首选药物 肾组织活检除明确LN分型，同时要评估狼疮活动度及慢性化指标,根据肾脏病理类型给予不同强度的治疗 狼疮性肾炎的治疗小结2 其他如MMF、CSA、氨甲喋呤、大剂量静注γ-球蛋白、他克莫司、氟达拉滨、克拉屈滨有报道在LN治疗中有作用，但尚无大规模前瞻性、随机、对照临床研究证实 Drugs 2003; 63 (2): 167-180 THE END ! * The keynote publication in 1986[15] of randomised trials performed at the NIH has set some kind of gold standard for treatment of patients with proliferative lupus nephritis. This study compared different strategies: prednisone alone, prednisone plus azathioprine, prednisone plus oral cyclophosphamide, and prednisone plus intermittent intravenous cyclophosphamide. A major observation was that only after long-term follow-up (at least 5 years) were significant differences found between strategies with respect to occurrence of renal failure. After 10 years of follow-up only patients treated with intravenous cyclophosphamide had a significantly better renal survival than those treated with prednisone alone. Despite the fact that no significant difference was found between this regimen and the one with azathioprine, treatment with intravenous cyclophosphamide has been accepted as the standard of treatment ever since. Compared with daily oral cyclophosphamide (usual dose for lupus nephritis being 1–3mg/kg
文档评论（0）