缺氧缺血性脑损伤与凋亡的进展.PDF

! 1318 ! hinese Journal of Pathophysiology 2004,20(7) : 1318- 1321 [ ] 1000- 4718(2004)07- 1318- 04 陈敏榕, 陈燕惠 (, 350001) Research progress in apoptosis and hypoxic- ischemic brain damage HEN Min- rong, HEN Yan- hui ( Dep artment of Ped iatric, Union H osp ital , Fuj ian Medical University , Fuzhou 350001, China) A Review Apoptosis is one of the most important causes, which results in the central neuronal system complication in hypoxic- ischemic brain damage (HIBD) . Apoptosis occurs in the developing brain more than in the developed brain. Apoptosis can last severalweeks and may be inverted its pathology by appropriate thera py. aspase inhibitor, neurotrophic factors, anti- apoptosis gene Bcl- 2, mild hypothermia, and early inter vention play important roles in promoting neuronal cell survival and preventing from apoptosis through different mechanisms. It may be a new way for rehabilitation of HIBD. [] ; , [KEY WORDS] Apoptosis; Hypoxia- ischemia, brain [ ] R72 [ ] A polymerase , PARP DNA ) , , , , , DNA- PK , Han [2] 6 hcaspase- 3 , 12- 18 h caspase- 3 , cas [ 1] [2] , , pase- 324 h , [ 19] , A1 caspase- 3mRNA , 1 [3] 24 h , 96 h 7 d , , Bcl- 2, caspase- 3 , , 90% [ 1] caspase caspase , 1 1 , ; 1(caspase) , caspase DNA , , , caspase [ 4] heng , , caspase BAF 7 d caspase caspase , HIBD ,