碘摄入量及富碘食物与甲状腺癌发病关系的Meta分析-肿瘤防治研究.PDF

616 2016 43 7  Cancer Res Prev Treat,2016,Vol.43,No.7 · · 肿瘤防治研究 年第 卷第 期 doi:10.3971/j.issn.1000-8578.2016.07.015 · · 流行病学 碘摄入量及富碘食物与甲状腺癌发病关系的 Meta分析 1 1 2 1 1 1 曹龄之 ，谢建平 ，彭小东 ，温琥玲 ，李素平 ，杨耀午 Association of Iodine Intake and Iodine-enriched Food with Risk of Thyroid Cancer: A Meta-analysis CAO Lingzhi1 1 2 1 1 1 , XIE Jianping, PENG Xiaodong , WEN Huling , LI Suping, YANG Yaowu 1. Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China; 2. Department of Oncology, The Second People’s Hospital of Chengdu, Chengdu 610000, China Abstract: Objective  To explore the relationship between iodine intake, iodine-enriched food and the risk  of thyroid cancer by Meta-analysis. Methods  We made search strategies according to PICOS. Pubmed,  Embase, CNKI, Wanfang and CBM databases were searched for case control studies or cohort studies about  the relationship between iodine intake, iodine-enriched food and the risk of thyroid cancer by computer from  the inception to April, 2015. The reference lists were scanned for relevant studies. The articles were screened  according to the inclusion and exclusion criteria by two researchers independently, the data were extracted, the  quality was evaluated, and then Meta-analysis was performed using Review Manager 5.2 and Comprehensive  Meta-Analysis V2. Results  A total of nine articles involving 5 374 participants were included. The results  of Meta-analysis showed that, more than adequate or excess iodine intake( 300 μg/day) or high consumption  ≥