生物資訊與網路資源.ppt

NCBI – Structure, MMDB, PTSI NCBI – Cn3D, PTSI structure ExPASy ExPASy - 2o structure prediction, GOR IV, PTSI ExPASy – 2o structure prediction, GOR IV, PTSI ExPASy – Topology prediction, SOSUI ExPASy – Topology prediction, SOSUI ExPASy – Topology prediction, SOSUI PDB PDB Web Resources Organization : NCBI/NIH, EBI/EMBL, SIB Database : GenBank, ExPASy, PDB Societies/Agencies : WHO, ASM Universities : NIH, CDC, Pasteur, 國衛院, 高速電腦中心, 清華, 陽明 Firms : Celera, Human Genome Sciences Conclusion Tremendous information on the web Promote biological sciences Solving problems and creating new hints/problems Use the information and generate new information 生物資訊與網路資源 Bioinformatics and Web Resources Bioinformatics(Computational Biology or Information Biology) Computational approaches to answer biological questions 使用電腦來解決生物學的問題 Bioformatics covers : 型態、結構、顏色 morphology,color DNA 及 基因體 genomes 蛋白質、碳水化合物等大分子 Biomacromolecules, proteome 生化、生理、遺傳、演化特性 biochemistry, physiology,genetics,evolution etc. NTHU清華大學 生物資訊與網路教學卓越計畫 清華大學 生物資訊與網路教學 卓越計畫 Bioinformatics : Revelations from the Book of Life …….BIOHRIACGTDSTRONGJKWISEGT TUSH……MLGHSINCERITYGKJ……….. CANCER ……...FEBEAUTYRANTGGGGCUP……… Bioinformatics Information can be converted into knowledge Promote human civilization and science achievements Creat knowledge-based economics Bioinformatics(Computational Biology or Information Biology) Why does it emerge so rapidly ? 1. Explosion of sequence and structural information 2. Advancement of Internet Bioinformatics The Three Projects Affecting Human Civilization most Menhatten Project 1940s Apollo Project 1965s Human Genome Project 1993-2003 Human Genome Project 1990-2003 Unravelling the 3 x 109 bp genome Goals 1. Understanding Life Science 2. Disease Diagnosis and Treatment Legal and Ethical Challenges 1. Human rights 2. Health insurance GOLD (Genomes OnLine Dat