胆盐代谢与转运和肝内胆汁淤积分子医学和临床相互促.pptVIP

胆盐代谢及转运和肝内胆汁淤积 ——分子医学和临床的相互促进 王建设 复旦大学附属儿科医院 复旦大学儿童肝病中心 “特发性”新生儿肝炎 GGT and the outcome July 1, 1981-Jan 1, 1985, 186 infants, 29 diagnosed as INHS, followed up for at least 1 year, or until death: 17 with increased GGT (=2.1*normal upper limit), All but 1 in good prognosis 12 with normal GGT, All poor prognosis Maggiore G, et al. J Pediatr, 1987;112:251-252. King’s病例入选标准 Aug 1991 to Nov 2000, Conjugated hyperbilirubinemia under 3 months of age (973 cases) No specific etiologic factor can be ascertained after comprehensive work-up Followed up for at least one year or until died 病例排除标准 INR1.