運用微晶片篩選癌症基因和探討其上游之調控.pptVIP

運用微晶片篩選癌症基因和探討其上游之調控 Contents Motivation Predict cancer genes based on microarray mRNA expression levels microRNA (miRNA) can act as an oncogene (OCG) or tumor suppressor gene (TSG) Identify cancer-related miRNAs, their target genes, downstream protein-protein interactions (prediction novel cancerous proteins) (1) Introduction – microarray, cancer, microRNA (2) Methods – input data (3) Results (a) cancer genes prediction (Bioconductor), i.e. prostate/breast cancer (b) correlation study of miRNAs and mRNA expression levels (c) ncRNAppi – A platform for studying microRNA and