HETEROCYCLIC COMPOUNDS Literature survey revealed that …：文献调查表明，杂环化合物….pdfVIP

__________________________INTRODUCTION_________________________ 1 HETEROCYCLIC COMPOUNDS Literature survey revealed that the history of heterocyclic chemistry beganinthe1800s,instepwiththedevelopmentoforganicchemistry[15]. AfterWorldWarII,therewasanenormousexplosionresearchinthefield ofheterocycles.Aboutonehalfofoversixmillioncompoundsrecordedin Chemical Abstracts are heterocyclic. Heterocyclic chemistry is one of the mostcomplexandintriguingbranchoforganicchemistryandheterocyclic compounds constitute the largest and most varied family of organic compounds.Manybroaderaspectsofheterocyclicchemistryarerecognized asdisciplinesofgeneralsignificancethatimpingeonalmostallaspectsof modern organic chemistry, medicinal chemistry and biochemistry. Heterocycliccompoundsofferahighdegreeofstructuraldiversityandhave proventobebroadlyandeconomicallyusefulastherapeuticagents. Heterocyclic compounds are organic compounds containing at least one atom of carbon and at least one element other than carbon, such as sulfur,oxygenornitrogenwithinaringstructure [6].Sinceinhetrocycles noncarbonsusuallyareconsideredtoreplacecarbonatoms,theyarecalled heteroatoms e.g. different from carbon and hydrogen. A ring with only heteroatoms is called homocyclic compound and heterocycles are the counterparts of homocyclic compounds. Thus incorporation of oxygen, nitrogen,sulfuroranatomofarelatedelementintoanorganicringstructure in place of a carbon atom gives rise to a heterocyclic compound. These structuresmaycompriseeithersimplearomaticringsornonaromaticrings. The heterocyclic compounds usually possess a stable ring structure which does not readily hydrolyzed or depolymerized. Heterocycles with three atomsintheringaremorereactivebecauseofringstrain.Thosecontaining ________________________________________________________________________ __________________________INTRODUCTION_________________________ 2 oneheteroatomareingenera