Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.突变CCL2蛋白涂层可在注入小鼠连续聚乙烯磨损粒子导骨质疏.pdfVIP

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Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model.突变CCL2蛋白涂层可在注入小鼠连续聚乙烯磨损粒子导骨质疏.pdf

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Biomaterials 117 (2017) 1e9 Contents lists available at ScienceDirect Biomaterials journal homepage: /l ocate/biomaterials Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model Akira Nabeshima a, Jukka Pajarinen a, Tzu-hua Lin a, Xinyi Jiang a, Emmanuel Gibon a, a, c a a € a d Luis A. Cordova , Florence Loi , Laura Lu , Eemeli Jamsen , Kensuke Egashira , Fan Yang a, b, Zhenyu Yao a, Stuart B. Goodman a, b, * a Department of Orthopaedic Surgery, Stanford University, Stanford, CA, USA b Department of Bioengineering, Stanford University, Stanford, CA, USA c Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Chile, Santiago, Chile d Department of Cardiovascular Research, Development, and Translational Medicine, Kyushu University, Fukuoka, Japan a r t i c l e i n f o a b s t r a c t Article history: Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Received 8 July 2016 Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 Received in revised form (MCP-1/CCL2) is the most important chemokine regulating trafﬁcking of monocyte/macrophages in 10 November 2016 particle-induced inﬂammation. 7ND recombinant protein