骨髓衰竭综合征课件.ppt

骨髓衰竭综合征;Case Presentation;Next Step;Pancytopenia with Hypocellular Marrow;Pancytopenia with Cellular Marrow;Bone Marrow (BM) Biopsy;Aplastic Anemia: Signs and Symptoms;Severity of Aplastic Anemia;Nosology of Aplastic Anemia;Acquired Aplastic Anemia;Evidence for Immune Disease;Copyright ?2006 American Society of Hematology. Copyright restrictions may apply.;Treatment for Acquired Aplastic Anemia;Overlapping Syndromes;Inherited Bone Marrow Failure Syndromes (IBMFS): Young Children;IBMFS: Adults and Older Children;IBMFS: Benign Hematology Oncology;History: Guido Fanconi;Fanconi Anemia - Children;Fanconi Anemia: Adults;Literature: Physical Findings;Laboratory Findings in FA;Fanconi Anemia - Definition;FANC Genes;FA Complementation Groups/Genes;FA DNA Repair Pathway;Who Should be Tested for FA?;What are the Tests for FA?;D2 Ubiquitination;Retrovirus-mediated Correction of TA 0252s T-cells analyzed by flow cytometry after five days of MMC-Incubation;FA Complications;FA Aplastic Anemia;FA Literature: Cancer 1927-2007;Risk of Cancer in FA by O/E Ratio;NCI FA Cumulative Incidence and Cause-specific Hazards;Competing Risks of Cancer;Fanconi Anemia: Phenotype/Outcome;Transplant and Head and Neck Cancer in Fanconi Anemia;Diagnosis of FA after Cancer;Hematopoietic Mosaicism ;Mosaicism from Recombination;FANCD1/BRCA2 Proband; Adult FANCA;Odds Ratios for Complications in FA and FANCD1/BRCA2;Genotype/Phenotype/Outcome: 27 FA with Biallelic Mutations in BRCA2;FANCD1/BRCA2 Mutations;FA: When to Treat;FA: How to Treat;FA Surveillance: Cancer;Case Presentation;Dyskeratosis Congenita;Dyskeratosis Congenita - Kids;Dyskeratosis Congenita - Adults;Physical Findings in DC;X-linked recessive (XLR), Autosomal dominant (AD), Autosomal recessive (AR) Mutations in telomerase and shelterin pathways: DKC1 (XLR) TERC (AD) TERT (AD, AR) TINF2 (AD);Major Complications in DC;44 cancers in 36/425 patients;What is the End of the Shoelace?;Telomeres and Chromosomal Instability;Telomere Biology Pa