微通道反应器中连续化合成苯亚甲基丙酮-大学化学.PDFVIP

Univ. Chem. 2019, 34 (5), 51−56 51   •化学实验• doi: 10.3866/PKU.DXHX201810009 微通道反应器中连续化合成苯亚甲基丙酮 ——介绍一个大学化学综合实验 * 李万梅 杭州师范大学材料与化学化工学院，浙江省化学实验教学示范中心，杭州 310036 摘要：微反应是近年来化学研究领域发展迅猛的一门新兴技术，本实验以苯甲醛和丙酮作为原料，在氢氧化钠作用下通 过缩合反应连续化合成苯亚甲基丙酮。通过对摩尔配比、停留时间、反应温度等影响因素的考查，确定了较佳反应条件， 并采用核磁和质谱对产品结构进行表征。与传统的批式方法相比，本实验方案具有收率高、操作简便、实验结果稳定等 优点。本实验将先进技术和理念寓于实验教学中，不仅增强了学生的实验技能，而且有助于学生了解科学前沿、研究现 状、发展方向和应用前景，激发学生的学习兴趣。 关键词：苯亚甲基丙酮；微通道反应器；连续化合成；综合实验 中图分类号：G64；O6 Continuous Synthesis of (E)Benzalacetonein Microchannel Reactor: An Introduction of a Comprehensive Chemical Experiment LI Wanmei * Provincial Experimental Teaching Demonstrating Center, College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, P. R. China. Abstract: Micro-reaction is an emerging technology that has been developing rapidly in recent years in all research fields of chemistry. In this experiment, benzaldehyde and acetone were used as the starting materials, thus (E)benzalacetone was continuously synthesized by condensation reaction in the presence of sodium hydroxide. By investigating effects of mole ratio, residence time and reaction temperature, the optimized reaction conditions were determined. The product was characterized by NMR and MS. Compared with traditional batch synthetic methods, the presented method has the advantages of high yield, simple operation, and reproducible experimental results. This work gives advanced technology and ideas in laboratory teaching, which not only enhances students’ experimental skills, but also helps students to understand the frontiers of science, research situation, tendency of development and application prospects, as w