Network and Pathway-Based Analyses of Genes Associated with Parkinson’s Disease 帕金森病相关基因的网络和路径分析.pdfVIP

Mol Neurobiol DOI 10.1007/s12035-016-9998-8 Network and Pathway-Based Analyses of Genes Associated with Parkinson’s Disease Yanshi Hu 1 Zhenhua Pan 1 Ying Hu 1 Lei Zhang2 Ju Wang 1 Received: 29 February 2016 /Accepted: 14 June 2016 # Springer Science+Business Media New York 2016 Abstract Parkinson’s disease (PD) is a major neurodegener- minimal tree algorithm and some potential related genes asso- ative disease influenced by both genetic and environmental ciated with PD were identified. In summary, by using factors. Although previous studies have provided insights into network- and pathway-based methods to explore pathogenetic the significant impacts of genetic factors on PD, the molecular mechanism underlying PD, results from our work may have mechanism underlying PD remains largely unclear. Under important implications for understanding the molecular mech- such situation, a comprehensive analysis focusing on biolog- anism underlying PD. Also, the framework proposed in our ical function and interactions of PD-related genes will provide current work can be used to infer pathological molecular net- us valuable information to understand the pathogenesis of PD. work and genes related to a specific disease. In the current study, by reviewing the literatures deposited in PUBMED, we identified 242 genes genetically associated Keywords Parkinson’s disease . Functional enrichment with PD, referred to as PD-related genes gene set (PDgset). analysis . Network analysis . Pathway crosstalk Functional analysis revealed that biological processes and bio- chemical pathways related to neurodevelopment, metabolism, and immune system were enriched in PDgset. Then, pathway Introduction crosstalk analysis indicated that the enriched pathways could be grouped into two modules, with