On-demand continuous-flow production of pharmaceuticals in a compact reconfigurable system 紧凑可重构系统中药品的按需连续流动生产.pdfVIP
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RESEARCH | RESEARCH ARTICLES
5. G. Pfeffer, K. Majamaa, D. M. Turnbull, D. Thorburn, General Hospital related to technology reported in this paper on SUPPLEMENTARY MATERIALS
P. F. Chinnery, Cochrane Database Syst. Rev. 4, CD004426 the use of hypoxia and the hypoxia response in the treatment of /content/352/6281/54/suppl/DC1
(2012). mitochondrial dysfunction. F.Z., O.S., and N.E.S. are listed as Materials and Methods
6. N. J. Lake, M. J. Bird, P. Isohanni, A. Paetau, J. Neuropathol. Exp. inventors on a patent application (PCT/US2013/074800) filed by Figs. S1 to S10
Neurol. 74, 482–492 (2015). The Broad Institute/MIT related to the genome-scale CRISPR Tables S1 and S2
7. G. S. Gorman et al., Ann. Neurol. 77, 753–759 (2015). knockout screening technology used in this study. The CRISPR References (41–44)
8. S. Parikh et al., Genet. Med. 17, 689–701 (2015). knockout library is available through a Uniform Biological Materials
9. R. H. Haas et al., Pediatrics 120, 1326–1333 (2007). Transfer Agreement from Addgene. The Ndufs4 KO mice were a 14 August 2015; accepted 9 February 2016
10. O. Shalem et al., Science 343, 84–87 (2014). kind gift of R. Palmiter and are available under a materials transfer Published online 25 February 2016
11. T. Wang, J. J. Wei, D. M. Sabatini, E. S. Lander, Science 343, agreement with the University of Washington, Seattle. 10.1126/science.aad9642
80–84 (2014).
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