儿童EBV感染与相关疾病诊疗讲谢正.pptVIP

CAEBV is characterized by severe, chronic or recurrent infectious mononucleosis-like symptoms after a primary EBV infection, and has a high morbidity and mortality from hepatic failure, lymphoma, sepsis, or hemophagocytic syndrome. 1. Unusual pattern of anti-EBV antibodies (high levels of IgG anti-VCA and EA, absence of anti-EBNA) High EBV viral load in peripheral blood Clonal expansion of EBV-infected T cells and NK cells Historical milestones of CAEBV 1948, Issacs: prolonged fever, malaise, lymphadenopathy, hepatosplenomegaly 1975, Horwitz et al:such clinical manifestations wi