第十三章有机含氮化合物2.pptVIP

Alkylation and Quaternary Ammonium Salts Quaternary Ammonium Compounds 胆碱(choline) 溴化乙酰胆碱(acetylcholine bromide) 乙酰胆碱(acetylcholine, ACh) 磷脂 Quaternary Ammonium Salts 两溶性 相转移催化剂 (Phase-transfer Catalyst) Phase-transfer Catalyst (三) Methylation and Hofmann Elimination Hofmann Elimination E2 elinmination Mechanism of the Hofmann elimination Methylation and Hofmann Elimination Hofmann’s rule: The less substituted alkene is preferred minor major Methylation and Hofmann Elimination Stereochemistry of Hofmann elimination E2 Trans elimination Methylation and Hofmann Elimination