细胞免疫医学知识宣讲讲义.ppt

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Cross presentation for CD8 priming Problem: how can na?ve CD8 cells get activated if activation requires peptide/MHC class I plus costimulation? This would require that professional antigen presenting cells get infected with virus, for example. A second problem is that viruses that manage to suppress MHC class I would evade detection. Cross presentation of exogenous proteins on MHC class I can be specifically carried out by dendritic cells. There is an important exception to the not