替格瑞洛分子及其早期研发.pptVIP

所有 patients administered 替格瑞洛 exhibited a 10% absolute reduction in platelet reactivity compared with 75% of patients administered 氯吡格雷 (p=0.005)[Gurbel 2010:E] Only 13% of patients administered 氯吡格雷 achieved a 30% absolute reduction in platelet reactivity compared with 75% of patients administered 替格瑞洛 (p0.001)[Gurbel 2010:E] Reductions of 50% were only observed in patients administered 替格瑞洛 (13% vs. 0%; p=0.046)[Gurbel 2010:E] There was no interaction in treatment efficacy between centres (p=0.0998) or time of measurement (p=0.2429)[Gurbel 2010:F] Gurbel PA, et al. Circulation 2010;121:1188