老年痴呆实验动物模型研制进展培训教材.pptVIP

Since abnormal PHF tau proteins could not perform the normal function of binding to and stabilizing microtubules (MTs) in the polymerized state, could further effect MT functions, especially fast axonal transport. The hypothesis: MT stabilizing drugs such as PaxceedTM delivering to the CNS could have therapeutic benefit in brains with tauopathies 假说 Hypothesis TaxolR (Paclitaxel, mw 854) -isolated in 1971 from plant, the pacific yew Taxus brevifonia -the first of a class of MT stabilizing drug which was approved for use in the treatment of breast, ovarian