PowerPoint-演示文稿---汕头大学医学院.pptVIP

* 尼达尔加心律平致皮肤反应 * 尼达尔加心律平致皮肤反应 * 急性肾功能衰竭 致过敏性紫癜和 环丙沙星和诺氟沙星 * 环丙沙星和诺氟沙星致过敏性紫癜 * 环丙沙星和诺氟沙星致过敏性紫癜 * 环丙沙星和诺氟沙星致过敏性紫癜 * 环丙沙星致双手剥脱性皮炎 * 环丙沙星致双手剥脱性皮炎 * 谢谢大家！ 你只闻到我的香水，却没看到我的汗水。 你否定我的现在，我决定我的未来！ 你嘲笑我一无所有，不配去爱，我可怜你总是等待。 你可以轻视我们的年轻，我们会证明这是谁的时代。 梦想是注定孤独的旅行，路上少不了质疑和嘲笑， 但那又怎样？ 哪怕遍体鳞伤，也要活得漂亮！ * Drug adverse reaction and drug-induced disease Department of Pharmacology Shantou University Medical College Yan-Qiong Zhou * Drug adverse reaction common/normal application dosage→harmful and unexpected reaction * Drug adverse reaction Side effect (副作用) toxic effect(毒性反应) Residual effect(后遗效应) dependence(依赖性) Idiosyncratic reaction/ Idiosyncrasy (特异质反应) allergic reaction/hypersensitive reaction (过敏反应/变态反应) Carcinogenesis, teratogenesis, mutagenesis(致癌、致畸和致突变反应) (not including Overdose; drug abuse; error treatment) * Drug-induced disease drug-induced functional or structural damage of the body; clinical course Essence: result/sequel of the Drug adverse reaction * Classify adverse reaction§drug dosage adverse reaction§peculiarity WHO;World Health Organization * adverse reaction§drug dosage concerned with dosage (A-type reaction)：有些药物不良反应与剂量大小有直接关系，这类反应也称为A型反应。 dosage indifference (B-type reaction)：某些药物不良反应与药物剂量无关，称为B型不良反应。 * A型与B型药物不良反应的特点 * adverse reaction§peculiarity side effect(副作用) toxic effect(毒性作用) residual effect(后遗效应) dependence(依赖性) idiosyncratic reaction(特异质反应) allergic reaction(变态反应) carcinogenesis(致癌作用) teratogenesis(致畸作用) mutagenesis(致突变作用) * adverse reaction classified by WHO side effect (副反应) adverse event (不良事件) adverse reaction (不良反应) unexpected adverse reaction (意外不良反应) signal(信号) * Aetiology of drug adverse reaction and drug-induced disease congenital abnormality of patient reaction病人反应先天性异常 Acquired abnormity获得性异常 drug factor药物因素 drug interactions 药物相互作用 Indirect reaction间接反应 * Congenital abnormality of patient reaction allergic/hypersensitive reaction Ⅰ、Ⅱ 、Ⅲ 、Ⅳ 、 autoimmune response genetic factor pharmacokinetics abnormality、pharmacodynamics