病毒性肝炎研究进展-庄辉.pptVIP

107 M W I E D F Y M S 195 196 I 198 210 158 164 99 121 124 137 138 139 107 149 147 G D --S-S- S-S S-S S-S Loop 1 of “a”determinant Loop 2 of “a”determinant 145 144 E R Alpha helicase ? Vaccine escape mutant ? Lamivudine resistant mutant F(苯丙)? Y(酪) E(谷) ? D(天冬) I(异白) ? M(蛋) W(色) ? S(丝) M(蛋) ? I(异白) D(天冬) ? E(谷) G(甘) ? R(精) Mock Mock Wild type Wild type G145R G145R D144E/G145R D144E/G145R F158Y F158Y E164D E164D W196S W196S M198I M198I I195M Anti-HBs 300mIU/ml Anti-HBs 1000mIU/ml A B 0 0.1 0.2 0.3 0.4 0.5 OD (450nm) OD (450nm) 0.5 0.4 0.3 0.2 0.1 0 I195M HBV