《海藻酸钠羟基磷灰石复合微球的制备及表征》【毕业设计论文】.docVIP

精品毕业论文 摘要 生物医用复合材料不仅兼具组份材料的性质,而且可以得到单组份材料不具备的新性能,为获得结构和性质类似于人体组织的生物医学材料开辟了一条广阔的途径,生物医用复合材料已经成为生物医用材料研究和发展中最为活跃的领域。 海藻酸钠/羟基磷灰石复合材料，因其组成结构类似于自然骨，具有良好的生物相容性、生物降解吸收性、生物活性等特点，而倍受人们的关注。海藻酸钠是一种酸性的多聚糖，具有良好的生物相容性，钙离子与海藻酸钠的 G 单元交联，可进一步获得网状的“鸡蛋盒”结构，成为良好弹性性能的水凝胶。人体骨中存在多聚糖，为了更好的模拟人体骨组成，有人已经通过机械混合、冷冻干燥制备了生物相容性好的羟基磷灰石/海藻酸钠复合材料。但是制备方法仅仅局限于羟基磷灰石和海藻酸钠溶液的简单混合。 本实验中研究有机-无机复合微球，采用水油系统的微乳液方法一步合成海藻酸钠/HA复合微球，通过扫描电镜研究表明预先合成的微球直径在7.5μm，尺寸分布很窄，具有很高的自然分散性和自然多孔结构。利用SEM、XRD、FT-IR光谱等手段对复合微球进行了表征和分析，证实了纳米羟基磷灰石颗粒成功包覆在海藻酸钠网络中。并考察了海藻酸钠浓度、海藻酸钠／HA质量比、分散剂用量、搅拌速度等因素对复合微球粒径、粒径分布以及形貌等的影响，确定了制备纳米羟基磷灰石/海藻酸钠复合微球的最佳条件，并借助不同手段对复合微球的粒径、粒径分布等进行了初步表征。 本实验首先采用4水硝酸钙为交联剂，实验结果出现塑料状不明物，后改用氯化钙实验才得以成功，具体问题有待进一步研究。 关键词：复合材料； 海藻酸钠； 羟基磷灰石； 原位合成 ABSTRACT Biomedical composite materials not only both components of the nature of the material, but also can get one of the new performance materials do not have, for the benefit of the structure and properties similar to human tissue biomedical material opened up a broad way, biomedical composites have been biomedical material research and development of the most active areas. Sodium alginate composite materials, / hydroxyapatite orbital implant for its composition structure similar to natural bone, has the good biocompatibility, biodegradable absorption sex, biological activity and other characteristics, and highly the attention of people. Alginate is a kind of acidic polysaccharide, has the good biocompatibility, calcium and sodium alginate G unit crosslinking, can further mesh of eggs box structure, become good elastic properties gel. Existing in human bone polysaccharide, in order to better simulating human bone composition, someone has been through the mechanical mixing, freeze drying was good biocompatibility hydroxyapatite/sodium alginate composite materials. But the preparation methods limited in hydroxyapatite and sodium alginate solution of the simple mix. The experimental research of organic and inorganic nanocomposite by water, oil system of microemulsion methods step