特罗凯在晚期NSCLC治疗中的应用.ppt

特罗凯在晚期NSCLC治疗中的应用 晚期NSCLC: 治疗目的? Longer life 延长总体生存 Better life 改善症状 延长TTP 改善疾病控制率 较低毒性* 改善QoL* * 在二线治疗时尤其重要 Treatment algorithm Chemotherapy: a balance between disease benefits and disadvantages for tolerability/QoL? Significant toxicity – myelosuppression – neuropathy Limited improvement in QoL i.v. administration Need for premedication Longer survival, few side effects and improvement in QoL are main improvements to current therapy requested by patients Randomised trials comparing new drug regimens 不良事件 3/4 度中性粒细胞减少 不良事件中性粒细胞减少性发热 二线化疗也达到了平台 结 论 对于PS 0-2分，一线和二