质谱培训教材.ppt

LTQ 液质联用仪培训教材 第一章 什么是质谱？ 怎样理解质谱 LC-MS LC-MSn 总离子流图 Mass Spectrometry “Simplified” (GMSD) 离子产生 (API) Atmospheric Pressure Ionization－大气压下离子化 离子源类型: Electrospray Ionization (ESI) 电喷雾电离 – 大多数情况下是液态过程 APCI (Atmospheric Pressure Chemical Ionization) 大气压下化学电离 – 气相过程 APPI (Atmospheric Pressure Photo-Ionization) 大气压下光离子化- 气相过程 离子源作用: Desolvate sample flow for introduction into mass spectrometer. 去溶剂 Baffle the first vacuum region of the MS from atmospheric pressure in the source. 真空过渡 Ionize the analyte or transport ion in solution to the gas phase. 离子化 Pump away neutrals and opposite char